It is uncertain           side effect the medicine will bring about, although about two thousand patients have taken it.
A．thatB．whatC．howD．whether
B
考查賓語從句。賓語從句中 bring about后缺少賓語，故用what 作定語修飾side effect，句意：還不清楚這種藥會(huì)帶來什么樣的副作用，雖然大約兩千名病人已經(jīng)服用過。故選B。
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