When ______ comes to research into heart disease and its effects on the body, we do not have adequate substitutes for the use of animals.
A．thatB．itC．thisD．what
B
考查固定句型：when it comes to“當(dāng)涉及…的時候”，句意是：當(dāng)涉及研究心臟病和它對身體的影響時，我們不會有適當(dāng)?shù)拇闷穪泶鎰游�。選B。
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