____fire, all exits must be kept clear. 
A．In place ofB．Instead ofC．In case ofD．In spite of
C
in case of意為“以防萬(wàn)一”,根據(jù)其賓語(yǔ)fire可判斷出“為了防止火災(zāi),一切出口都要清除干凈”。in place of 意為“代替”。instead of 意為“代替,而不是……”。in spite of 意為“不管”。
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