－Doctor,________ should I take this medicine?

－Twice a day．

[　　]

A．

what time

B．

how much

C．

how soon

D．

how often

答案：D
解析：

　　what time意為“什么時間”;how often表示“多久一次”，指動作的頻率;how soon表示“還要多久才……”,一般用于將來時，回答用“in…”; how much表示“多少”，后面接不可數(shù)名詞。而答語Twice a day．表示頻率，故選D。


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